Methotrexate

Create a 3D molecule model of the chemotherapy drug Methotrexate (Amethopterin) utilizing Genuine Molymod Model Parts by Indigo.

Methotrexate's chemical structure can be described as a pteridine, as well as a monocarboxylic acid amide and a dicarboxylic acid & is functionally related to the amino acid, L-glutamic acid.

Methotrexate is a chemotherapy drug. It is most commonly associated with treatment of acute lymphoblastic leukemia, non-Hodgkin lymphoma as well as osteosarcoma & breast & lung cancer, osteosarcoma. It also has uses as an antirheumatic medication for autoimmune diseases such as rheumatoid arthritis; skin treatment of psoriasis caused by lupus; and inflammatory bowel disease (Crohn's).

A molecular model of Methotrexate in the Molymod Hybrid Dome style uses the atoms & bonds in the parts list below. Our free 3D Molecular Model Builder shows other styles & allows for image rotation as an assembly guide.

Chemical data
Molecular Weight Chemical Formula
454.4444 C20H22N8O5

Methotrexate molecular model built with Molymod Atoms & Bonds

Hybrid Dome
62053
Open Sphere
62009
Orbit Basic
68845NV
Orbit Flexible
68827W 68847W
Parts Synonyms
Parts
P/NDescriptionQTY
60150EAtom, Molymod, white (hydrogen), hemisphere, 19mm22
60200EAtom, Molymod, red (oxygen), 2 hole, 105 degrees5
60311EAtom, Molymod, blue (nitrogen), 3 hole, 120 degrees, 23mm4
60400EAtom, Molymod, black (carbon), 4 hole, 109.5 degrees, 23mm20
60401EAtom, Molymod, blue (nitrogen), 4 hole, 109.5 deg., 23mm4
61012EBond, Molymod, grey (single), 20mm24
61013EBond, Molymod, grey (double/triple), 35mm22
61015EBond, Molymod, opaque, 2mm (for spacefilling models)22
Synonyms
IUPAC Name: (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid , InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1 , InChIKey: FBOZXECLQNJBKD-ZDUSSCGKSA-N , SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O , CAS: 59-05-2 , (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid , (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioic acid , (2S)-2-[[[4-[(2,4-diamino-6-pteridinyl)methyl-methylamino]phenyl]-oxomethyl]amino]pentanedioic acid , (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]glutaric acid , (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]phenyl]carbonylamino]pentanedioic acid , Maxtrex , Metolate ,