Use ammonia cloth to detect faulty gloves or sleeve assemblies to prevent contamination of isolator integrity. This image shows the use of the ammonia leak detector cloth in action on a glove port of an isolator.
An ammonia high pressure leak test of pharmaceutrical isolators helps ensure an aseptic environment. Ammonia cloth's sensitivity can limit the risk of microbial migration through microscopic holes.
Excerpt below is taken from: Leak Rate Measurement for Pharmaceutical Isolators: Practical Guidance for Operators and Test Engineers. Clean Air and Containment Review Issue 11, pgs. 8-12.
Ammonia provides an excellent method for leak detection. It is sensitive, inexpensive and will trace small leaks with absolute repeatability. To carry out this test, a bottle of around 50 ml of ammonia solution is placed inside the isolator together with a pad of lint-free wipers and a polyethylene bag. The isolator is sealed up and using the gloves, the ammonia is poured out onto the wipers to disperse through the isolator volume. The isolator is then raised to perhaps 100 Pa pressure and proprietary bromophenol cloth is applied to the seals and joints of the isolator. Where ammonia escapes, the cloth turns from yellow to blue. At the end of the test the wipers are placed in the plastic bag and the isolator is ventilated, ideally to atmosphere. Ammonia is of course pungent, but the quantities used are small and the real hazards are small. This method is highly recommended to isolator users."
This paper on leak detection discusses the theory & methods for conducting accurate leakage rate measurements.
From the Walker Barrier Systems brochure.
Ammonia Leak Cloth Documentation |
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